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Two patients with the Wiskott- Aldrichsyndrome had complete donor lymphoid and hematopoietic engraftment after successful allogeneic bone-marrow transplantation.
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The Wiskott- Aldrichsyndrome (WAS) is an X-linked recessive genetic disease in which the basic molecular defect is unknown.
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Background: Proliferation and IL-2 production in response to T-cell receptor ligation are impaired in patients with Wiskott- Aldrichsyndrome (WAS).
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This treatment of the Wiskott- Aldrichsyndrome may be a model for the correction of other genetically determined immune and hematologic bone-marrow disorders.
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The Wiskott- Aldrichsyndrome is an X-linked hereditary disorder associated with combined immunodeficiency, thrombocytopenia, small platelets, eczema, and increased susceptibility to autoimmune disorders and cancers.
Entomological research institute co-administered by the USDA and the Smithsonian Institution.